5 Simple Statements About LDN-27219 side effects Explained
One particular notably intriguing compound is LDN-27219. Whilst most tTG inhibitors are made to bind to the protein crosslinking Lively internet site, LDN-27219 alternatively binds for the nucleotide binding pocket from the enzyme though it really is in its shut-state conformation, and stabilizes that conformation to prevent crosslinking activity.s